News
 International
   Global Views
   Asia-Pacific
   America
   Europe
   Middle East & Africa
 National
 Embassy News
 Arts & Living
 Business
 Travel & Hotel
 Medical Tourism New
 Taekwondo
 Media
 Letters to Editor
 Photo Gallery
 News Media Link
 TV Schedule Link
 News English
 Life
 Hospitals & Clinics
 Flea Market
 Moving & Packaging
 Religious Service
 Korean Classes
 Korean Weather
 Housing
 Real Estate
 Home Stay
 Room Mate
 Job
 English Teaching
 Translation/Writing
 Job Offered/Wanted
 Business
 Hotel Lounge
 Foreign Exchanges
 Korean Stock
 Business Center
 PR & Ads
 Entertainment
 Arts & Performances
 Restaurants & Bars
 Tour & Travel
 Shopping Guide
 Community
 Foreign Missions
 Community Groups
 PenPal/Friendship
 Volunteers
 Foreign Workers
 Useful Services
 ST Banner Exchange
  Asia-Pacific
A Bouquet of Novel Compounds: New Treatment Options for HIV
Special Contribution
By Shobha Shukla
HIV: There is no known cure for HIV (human immunodeficiency virus). Experts say that proper medical care can control HIV. HIV virus destroys important cells that fight disease, thus weakening immune system.
It was 40 years ago when the first case of HIV infection was diagnosed. Since then, 77.5 million people have been infected with the virus and 34 million people have died from AIDS-related causes. While a lot has been achieved in terms of providing lifesaving antiretroviral treatment to save lives, we still lost 690,000 people living with HIV to AIDS-related illnesses in 2020. Even today more than 10 million (27%) of the 37.6 million people living with HIV are not on treatment. Moreover, "we are getting signals of HIV drug resistance, which means we need to strengthen our surveillance efforts and continue to invest in long-acting prevention and treatment tools, in the absence of an HIV vaccine, and also remember that solutions we find may not be one size that fits all", said Dr. Adeeba Kamarulzaman, President of the International AIDS Society (IAS), during the closing session of the recently concluded 11th International IAS Conference on HIV Science (IAS 2021).

This article, second in the series of an exclusive trilogy by CNS head and IAS HIV Science 2021 Media Fellowship Awardee Shobha Shukla, showcases some recent scientific advances made in the new drug pipeline for HIV treatment, that were discussed during IAS 2021.

Reiterating the need for developing new treatment options for people living with HIV, Professor Chloe Orkin, Clinical Professor at Queen Mary University of London said, ¡°There are people who need new treatments- those in whom the drugs do not work anymore; or those who cannot swallow or tolerate oral medications (including children) or those who find it very challenging to adhere to daily regimens due to a variety of reasons.¡±

Several long-acting HIV treatment modalities including injectable, oral, implant, or antibody therapy are currently under different stages of development.

Long acting cabotegravir/ rilpivirine monthly and 2-monthly injectable

This 2-drug long-acting injectable antiretroviral-based regimen for maintenance of viral load suppression consists of Rilpivirine (a non-nucleoside reverse transcriptase inhibitor) and Cabotegravir (an integrase inhibitor).

It has already been approved and licensed for use in the European Union (EU) and in USA.

Cabotegravir/ Rilpivirine intramuscular injections can be used by those people living with HIV who are on oral antiretroviral therapy. are virally suppressed for at least three months, and are not resistant to either of these drugs and do not have active Hepatitis B (as Cabotegravir cannot treat Hepatitis B, while a Tenofovir disoproxil fumarate (TDF) and Tenofovir Alafenamide (TAF) regimen does). Pregnant women are excluded from using this injectable, because as of now there is no clinical data for them.

Three key phase-3 studies- FLAIR, ATLAS and ATLAS 2M- have evaluated the safety and efficacy of long-acting Cabotegravir/ Rilpivirine injection for treatment of HIV, with Orkin being the lead author of the FLAIR study.

FLAIR tested Cabotegravir/ Rilpivirine in those people living with HIV who were initially treatment-naive. They were then put on their 1st oral combination treatment. Once their viral load became undetectable they were given Cabotegravir/ Rilpivirine regimen.

ATLAS study involved people who were already on oral antiretroviral therapy and had undetectable viral load. ATLAS 2M study evaluated if the treatment duration could be increased to once every two months and was done on people who were already on monthly Cabotegravir/ Rilpivirine.

The regimen was found to be safe and well tolerated. Efficacy outcomes in all these studies were non-inferior to daily oral regimens. Moreover, patient satisfaction was very high. Across these studies, participants said they preferred the monthly or bimonthly injections over daily pills, and patients previously receiving Cabotegravir/ Rilpivirine preferred dosing every 8 weeks over every 4 weeks.

However there was a very low failure rate of 1.5% in the study participants. The participants who failed the regimen developed resistance for both Cabotegravir and Rilpivirine. Those who failed either had some underlying resistance to Rilpivirine at baseline, or had low levels of Rilpivirine at 8 weeks, or had any of the two HIV subtypes (A6/A1).

¡°But you can suppress the failure by using a protease inhibitor combination. And we do have now, Cabotegravir single tablet protease inhibitor combination that can be used if one fails on Cabotegravir/ Rilpivirine,¡± said Orkin.

Islatravir/ Doravirine

Islatravir is a nucleoside transcription translocation inhibitor, it has a long half life, inhibits viral replication, and its multiple mechanisms of action contribute to its high potency and high barrier to resistance, including drug resistant viruses.

In combination with Doravirine, it has demonstrated high potency and good tolerability. A phase-2b study evaluating the safety and efficacy of Islatravir/ Doravirine in treatment naive adult people with HIV shows that at week-96 after starting treatment, 90% of the participants maintained viral suppression and no viral resistance was identified, showing that this two drug combination has the potential to be a potent two-drug regimen that works as well as a standard three-drug regimen.

Islatravir/Doravirine is now undergoing testing in a comprehensive clinical development programme. This includes phase-3 studies in treatment-naive people (NCT04233879), heavily treatment-experienced people (NCT04233216) and people with viral suppression who are switching from other regimens (NCT04223778 and NCT04223791). A phase-2 study of children and adolescents is also planned (NCT04295772).

Islatravir is also in development as a once-weekly oral treatment regimen in combination with a new compound (MK-8507, a non-nucleoside reverse transcriptase inhibitor). In addition it is being developed as monthly oral PrEP and as a yearly PrEP implant.

Long-acting Lenacapavir

Lenacapavir is a potent capsid protein inhibitor, it is in clinical development as an oral pill, and as a subcutaneous long-acting injection. Lenacapavir has been found to maintain target concentration in the body for 26 weeks and can potentially be used as a 6 monthly subcutaneous injectable.

Results of two studies CAPELLA and CALIBRATE show the potential of Lenacapavir as a long-acting treatment option for treatment-naive patients as well as for those failing treatment.

CAPELLA is an ongoing Phase-2/3 multi-centre study to evaluate safety and efficacy of subcutaneous long-acting Lenacapavir in heavily treatment experienced people living with HIV, whose current antiretroviral therapy was not working, and who had multi-drug resistance. The results covering the first 26 weeks of the study show that subcutaneous Lenacapavir, in combination with optimized background regimen, achieved an undetectable viral load below 50 in 81% of the participants. Lenacapavir was found to be safe and well tolerated.

CALIBRATE is an ongoing Phase-2 induction maintenance study to evaluate safety and efficacy of Lenacapavir subcutaneous (dosed every 6 months) as part of a combination regimen in treatment-naïve persons with HIV. The interim 16 weeks results presented at IAS 2021 show that Lenacapavir, given subcutaneously or orally, in combination with Emtricitabine/ Tenofovir Alafenamide led to high rates of viral suppression in treatment-naïve persons with HIV by week-16th. Lenacapavir was generally safe and well-tolerated. These results support the ongoing evaluation of Lenacapavir for treatment and prevention of HIV infection, and also for taking Lenacapavir forward into studies combining it with Islatravir as an injection-only regimen.

In fact Gilead Sciences (developer of Lenacapavir) and Merck (developer of Islatravir) are joining hands to to develop an injectable treatment using Lenacapavir/ Islatravir just like Cabotegravir/ Rilpivirine. But this will be a much longer acting treatment. Studies are expected to begin in 2022, said Orkin.

Maturation inhibitors

There are other drugs in development too, like Maturation Inhibitors being developed by GSK (GSK254 and GSK937). Maturation inhibitors block protein processing late in the viral replication cycle. ViiV is progressing with oral and long-acting maturation inhibitors programmes targeting frequency of once every two months.

Broadly neutralizing antibodies have potential for long-acting treatment as well as prevention option!

Broadly neutralising antibodies could be the next generation HIV treatment and prevention regimens. They can recognise and block the entry of a broad range of different strains of HIV into healthy cells, and have the potential to contribute to long-acting treatment as well as prevention. Human studies have shown antiviral activity. Animal studies (in monkeys) have shown remission. They have the potential to contribute to long-acting treatment. ViiV Healthcare has recently announced the development of the investigational broadly neutralizing antibodies (bNAb N6LS) for the treatment and prevention of HIV-1.

HIV Vaccine: When will it be there?

The aim is to develop a global prophylactic vaccine that is effective for the all the relevant strains of HIV against multiple modes of transmission.

At IAS 2021, the Global HIV Vaccine Enterprise shared some updates from two complementary ongoing HIV vaccine efficacy studies- Imbokodo Phase 2b (HVTN 705) study is ongoing in 5 countries in Southern Africa (where Clade C of HIV subtype-1 is predominant) in heterosexual young women for intra-vaginal transmission mode and Mosaico Phase 3 (HVTN 706) in the Americas and Europe (where Clade B of HIV subtype-1 is predominant) in gay men and transgender individuals for intra-rectal transmission mode. But to support a broad evidence package immuno-bridging studies will have to be done- bridging between regimens, between populations and between clades.

While an HIV vaccine is still far off, long-acting formulations are in advanced stages of development to overcome barriers posed by daily oral therapy- adherence issues, pill fatigue, or stigma associated with taking daily oral pills and, above all, to improve the quality of life of people living with HIV.



Related Articles
    Early and Accurate TB Diagnosis Is the Gateway ...
    Long Walk to Transgender Rights and Gender ...
    Strong Local Actions Are Pivotal to Reduce ...
    The Head Must Follow What the Hand Writes
    Ending Tobacco Smoking Is Bedrock for ...
    Asia Pacific Has over 6.7 Million New TB Cases
    Will Shorter, Safer and More Effective TB ...
    Whither Women's Reproductive Health in Asia ...
    Build the World We Want: Healthy Future for All
    New TB Treatment Breakthroughs Must Reach the ...
    How Will Children Living with HIV Grow Up ...
    Writing Is on the Wall: Pictorial Health ...
    Failing on the Basics: Are We Able to Break ...
    One Size Does Not Fit All: Expanding the ...
    Tale of Two Pandemics: Follow the Science and ...
    Governments Must Adopt a Strong Political ...
    What Is the Ring?
    Disability Is Not Limited to the Body, It Is ...
    Accelerating Progress on Sexual & Reproductive ...
    Stop This Shaming of Menstruation
    Complacency Breeds Failure: Consolidate ...
    For Age Is Opportunity No Less Than Youth ...
    New Study Pegs the Number of TB Cases in India ...
    Self-stigma: Let Us Do More Than Just "Ttalk ...
    We Cannot Eliminate TB If We Leave Children ...
    MDR-TB Treatment Rgimen: Short Indeed Is ...
    A Plain Face Can Take the Sheen Out of Deadly ...
    Strike at the Root of the Problem to Kill TB
    Antibiotic Use Is Driving Antibiotic Resistance
    Big Push for Transgender and Hijra Welfare
    Where There Is a Will There Is a Way: Teeja ...
    Lung Cancer: Difficult to Diagnose, Difficult ...
    Long Road to Justice: Human Rights of Female ...
    Medical Malpractices: Is There Light at the ...
    Overcoming Roadblocks in Translating ...
    Management of Respiratory Diseases beyond ...
    Gender Justice to Be at the Heart of ...
    Connecting the Dots: Tobacco Use, Diabetes, ...
    It Is Time To Control Asthma
    Call for No More New HIV Infected Children
    Smoking Goes Electronic
    Break the Silence around Cancer
    How Can You Treat Your Illness Unless You Take ...
    Asthma Medicines Still Unaffordable for Many
    New Technique to Prevent Diabetic Lower-Limb ...
    Cycle Beads: The Bead String for Family ...
    Beware: All Forms of Tobacco Are Harmful!
    Mother's Milk Is the Best Nutrition for the ...
    Where Is The TB Quilt, Nay Mask?
    Hello, This Is Nature¡¯s Call From Garbage ...
    Tuberculosis: Ugly Scar on Beautiful Childhood
    Towards A More Enabling Environment for ...
    What¡¯s Cooking in Kitchen: Peace or Conflict?
    Feed Your Child Well: Prevent Pneumonia
    Costly Medicines Mean Debt or Death for People ...
    AIDS Epidemic at a Critical Juncture in ...
    Watch Your Tongue Mr. Minister!
    Free Trade Agreements: A Threat To People's ...
    In The Pursuit Of Healthy Happiness
    Empowering Rural Women
    Say Yes To Life: Say No To Tobacco
    Homophobia Is A Human Rights Issue
    Viva La Woman Power
    Rubbish Rubbish Food and Embrace Healthy ...
    Of Music and Divinity
    Wake Up Call on Childhood Obesity after Years ...
    A New Hope of Life for Our Ailing Education ...
    Reminiscences of Egypt
    Do Not Break the Nucleus
    Whispers of Sanity in the Frenzy of Madness
    Tobacco Cessation Can Piggy-back Ride on ...
    In The Spirit Of Freedom (from Tobacco)
    World Conference on Tobacco or Health to ...
    Requiem for Purity
    Rhapsody 2008 -- a Symphony of Different ...
    'Diabetes Doctor Is at Your Doorstep' in ...
    Activists Decry India's Deferment of Pictorial ...
    South-East Asian Diabetes Summit to Open Up in ...
    Special on Universal Children's Day
    The Wrath Of God
    World Food Scarcity and the Challenges of ...
    Victim of Terrorism -- the Common Man
    Teachers' Day: The Sacrificial Goat
    Hiroshima Day: Let Us Worship Peace and Shun ...
    Whither the Innocence of Childhood?
    Food for Thought -- on World Food Day
    Love Is the Missing Link in War-on-Terror
    Irom Sharmila: The Iron Lady
    India Poised And Shining
    Is It Just Another Day in Life of Indian Woman?
    He Has His Cake and Eats It Too
    To Be Young, to Be Married, and to Be in India
    The Mad Mad World of Ads

Other Articles by Shobha Shukla
    Long Walk to Transgender Rights and Gender ...
    Whither Women's Reproductive Health in Asia ...
    Build the World We Want: Healthy Future for ...
    New TB Treatment Breakthroughs Must Reach ...
    One Size Does Not Fit All: Expanding the ...


Ms. Shobha Shukla has been teaching physics at India's noted Loreto Convent, and has written for The Hindustan Times and Women's Era in the past. She serves as editor of Citizen News Service (CNS). She can be contacted at shobha1shukla@yahoo.co.in)

 

back

 

 

 

The Seoul Times, Shinheung-ro 36ga-gil 24-4, Yongsan-gu, Seoul, Korea 04337 (ZC)
Office: 82-10-6606-6188 Email:seoultimes@gmail.com
Copyrights 2000 The Seoul Times Company  ST Banner Exchange